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CAS No.: 34576-94-8
Synonyms: 3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM.
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技术信息
CAS号 | 34576-94-8 | 储存条件 |
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分子式 | C9H4Cl2O2S | 运输 | 蓝冰 | |||
分子量 | 247.10 | 别名 | 3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid | |||
溶解度 |
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